???? Major Rhubarb Combination (interior-attacking formula) Effects: purging heat and eliminating stasis; eliminating stuffiness and fullness. Indications: yang brightness bowel pattern/syndrome- difficulty in defecation due to stomach excess induced by yang pathogen entering the interior; fever and delirious speech; spontaneous sweating without aversion to cold; simultaneous occurrence of stuffiness, fullness, dryness, excess and hardness; triple energizer with sunken replete pulse, or yang brightness febrile convulsion with chills . Clinical Reference: This formula is often used in treating febrile diseases; hypertension; weak foot; heat manic psychosis; infantile acute epilepsy; food poisoning; habitual constipation; obesity; dysentery; hemorrhoid; bleeding piles.