Eucommia & Rehmannia Formula (tonifying and replenishing formula) Effects: warm-tonifying kidney yang; increasing and improving essence/blood. Indications: insufficiency of the kidney yang; debilitation of the life gate fire; marrow deficiency and aversion to cold; weakness of the loin and knees; anemia; impotence and seminal emission. Clinical Reference: This formula is often used in treating the kidney yang insufficiency; debilitation of the life gate fire; the aged with a prolonged illness; deficiency of qi and weary of spirit; aversion to cold; cold limbs; impotence; spermatorrhea; inappetence; enuresis (incontinence of urine).